Comparison of Capillary Electrophoresis with Cellulose Acetate Electrophoresis for the Screening of Hemoglobinopathies
نویسندگان
چکیده
منابع مشابه
Comparison of capillary electrophoresis with cellulose acetate electrophoresis for the screening of hemoglobinopathies.
BACKGROUND β-thalassemia is primarily found in individuals of Mediterranean and Southeast Asian ancestry. With rapid growth in the Southeast Asian segments of the Korean population, the geographic distribution of hemoglobinopathies is expected to become significantly different from what it is today. In this study, Hb fractions were measured in patients with hypochromic microcytosis to detect th...
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Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...
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Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...
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by addition of calculated amounts of 200 g/L glucose. Serum glucose concentrations attained by this procedure were controlled by measurement with the Beckman Glucose Analyzer. The sensitivity to glucose (calculated for the range 5–10 mmol/L) in phosphate buffer (pH 7.4) was 10.2 Ϯ 3.3 nA ⅐ L ⅐ mmol Ϫ1 (mean of slopes calculated from each experiment Ϯ SE; Fig. 1A).The sensitivity to glucose afte...
متن کاملIdentification of hemoglobins and hemoglobinopathies by electrophoresis on cellulose acetate plates impregnated with citrate agar.
We describe a method of electrophoresis of hemoglobin on cellulose acetate plates impregnated with citrate agar, which remain stable for many months and are used to confirm rapidly the presence of hemoglobins S and C and the hemoglobinopathieS associated with them. The method also provides excellent separations of hemoglobins F and A and reliable identification of genetically determined hemoglo...
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ژورنال
عنوان ژورنال: Annals of Laboratory Medicine
سال: 2011
ISSN: 2234-3806,2234-3814
DOI: 10.3343/kjlm.2011.31.4.238